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The differential expression of osteoprotegerin (OPG) and receptor activator of nuclear factor κB ligand (RANKL) in human osteoarthritic subchondral bone osteoblasts is an indicator of the metabolic state of these disease cells

OBJECTIVE: We previously reported that human OA subchondral bone osteoblasts could be discriminated into two subpopulations identified by their levels of endogenous production (low [L] or high [H]) of PGE(2). Here, we investigated the OPG and RANKL expression levels, the histologic analysis of the s...

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Detalhes bibliográficos
Publicado no:Clin Exp Rheumatol
Main Authors: Tat, Steeve Kwan, Pelletier, Jean-Pierre, Lajeunesse, Daniel, Fahmi, Hassan, Lavigne, Martin, Martel-Pelletier, Johanne
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247261/
https://ncbi.nlm.nih.gov/pubmed/18565252
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