Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development

Vascular development depends on the highly coordinated actions of a variety of angiogenic regulators, most of which apparently act downstream of vascular endothelial growth factor (VEGF). One potential such regulator is delta-like 4 ligand (Dll4), a recently identified partner for the Notch receptor...

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Detalhes bibliográficos
Main Authors: Gale, Nicholas W., Dominguez, Melissa G., Noguera, Irene, Pan, Li, Hughes, Virginia, Valenzuela, David M., Murphy, Andrew J., Adams, Niels C., Lin, Hsin Chieh, Holash, Jocelyn, Thurston, Gavin, Yancopoulos, George D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2004
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC524697/
https://ncbi.nlm.nih.gov/pubmed/15520367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407290101
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