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Embryonic stem cell tumor model reveals role of vascular endothelial receptor tyrosine phosphatase in regulating Tie2 pathway in tumor angiogenesis

Inhibiting angiogenesis has become an effective approach for treating cancer and other diseases. However, our understanding of signaling pathways in tumor angiogenesis has been limited by the embryonic lethality of many gene knockouts. To overcome this limitation, we used the plasticity of embryonic...

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Detalhes bibliográficos
Main Authors: Li, Zhe, Huang, Hui, Boland, Patricia, Dominguez, Melissa G., Burfeind, Patricia, Lai, Ka-Man, Lin, Hsin-Chieh, Gale, Nicholas W., Daly, Christopher, Auerbach, Wojtek, Valenzuela, David, Yancopoulos, George D., Thurston, Gavin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794035/
https://ncbi.nlm.nih.gov/pubmed/20018779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0911189106
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