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Concerted bis-alkylating reactivity of clerocidin towards unpaired cytosine residues in DNA
Clerocidin (CL) is a topoisomerase II poison, which cleaves DNA irreversibly at guanines (G) and reversibly at cytosines (C). Furthermore, the drug can induce enzyme-independent strand breaks at the G and C level. It has been previously shown that G-damage is induced by alkylation of the guanine N7,...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2004
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC524306/ https://ncbi.nlm.nih.gov/pubmed/15494453 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh898 |
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