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Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action

Clerocidin (CL) is an effective topoisomerase II-poison, which has been shown to produce DNA depurination and strand breaks per se at the guanine (G) level. To elucidate the roles played by the different functional groups of CL in the reactivity towards nucleic acids, we investigated CL derivatives...

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Udgivet i:Nucleic Acids Res
Principais autores: Richter, Sara, Gatto, Barbara, Fabris, Daniele, Takao, Ken-ichi, Kobayashi, Susumu, Palumbo, Manlio
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2003
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Articles
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC212796/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12930966/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg696
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