Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action

Clerocidin (CL) is an effective topoisomerase II-poison, which has been shown to produce DNA depurination and strand breaks per se at the guanine (G) level. To elucidate the roles played by the different functional groups of CL in the reactivity towards nucleic acids, we investigated CL derivatives...

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Detaylı Bibliyografya
Asıl Yazarlar: Richter, Sara, Gatto, Barbara, Fabris, Daniele, Takao, Ken-ichi, Kobayashi, Susumu, Palumbo, Manlio
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2003
Konular:
Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC212796/
https://ncbi.nlm.nih.gov/pubmed/12930966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg696
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