Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action

Clerocidin (CL) is an effective topoisomerase II-poison, which has been shown to produce DNA depurination and strand breaks per se at the guanine (G) level. To elucidate the roles played by the different functional groups of CL in the reactivity towards nucleic acids, we investigated CL derivatives...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Richter, Sara, Gatto, Barbara, Fabris, Daniele, Takao, Ken-ichi, Kobayashi, Susumu, Palumbo, Manlio
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2003
Assuntos:	Articles
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC212796/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12930966/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg696
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