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Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action
Clerocidin (CL) is an effective topoisomerase II-poison, which has been shown to produce DNA depurination and strand breaks per se at the guanine (G) level. To elucidate the roles played by the different functional groups of CL in the reactivity towards nucleic acids, we investigated CL derivatives...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2003
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC212796/ https://ncbi.nlm.nih.gov/pubmed/12930966 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg696 |
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