Clerocidin alkylates DNA through its epoxide function: evidence for a fine tuned mechanism of action

Clerocidin (CL) is an effective topoisomerase II-poison, which has been shown to produce DNA depurination and strand breaks per se at the guanine (G) level. To elucidate the roles played by the different functional groups of CL in the reactivity towards nucleic acids, we investigated CL derivatives...

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Bibliographic Details

Published in:	Nucleic Acids Res
Main Authors:	Richter, Sara, Gatto, Barbara, Fabris, Daniele, Takao, Ken-ichi, Kobayashi, Susumu, Palumbo, Manlio
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2003
Subjects:	Articles
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC212796/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12930966/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg696
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