Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart‐related traits

Traditionally, genomewide association studies (GWAS) have emphasized the benefits of large samples in the analyses of age‐related traits rather than their specific properties. We adopted a realistic concept of genetic susceptibility to inherently heterogeneous, age‐related traits driven by the elusi...

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Pubblicato in:Aging Cell
Autori principali: Kulminski, Alexander M., Kernogitski, Yelena, Culminskaya, Irina, Loika, Yury, Arbeev, Konstantin G., Bagley, Olivia, Duan, Matt, Arbeeva, Liubov, Ukraintseva, Svetlana V., Wu, Deqing, Stallard, Eric, Yashin, Anatoliy I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242299/
https://ncbi.nlm.nih.gov/pubmed/27683205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12526
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