Effect of the APOE Polymorphism and Age Trajectories of Physiological Variables on Mortality: Application of Genetic Stochastic Process Model of Aging

We evaluated effects of the APOE polymorphism (carriers versus noncarriers of the e4 allele) and age trajectories of total cholesterol (CH) and diastolic blood pressure (DBP) on mortality risk in the Framingham Heart Study (original cohort). We found that long-lived carriers and noncarriers have dif...

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Main Authors: Arbeev, Konstantin G., Ukraintseva, Svetlana V., Kulminski, Alexander M., Akushevich, Igor, Arbeeva, Liubov S., Culminskaya, Irina V., Wu, Deqing, Yashin, Anatoliy I.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653307/
https://ncbi.nlm.nih.gov/pubmed/23682334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.6064/2012/568628
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