The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD)

Regulatory T (Treg) cells expressing the transcription factor FOXP3 play a pivotal role in maintaining immunologic self-tolerance. We and others have shown previously that EZH2 is recruited to the FOXP3 promoter and its targets in Treg cells. To further address the role for EZH2 in Treg cellular fun...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Sarmento, Olga F., Svingen, Phyllis A., Xiong, Yuning, Sun, Zhifu, Bamidele, Adebowale O., Mathison, Angela J., Smyrk, Thomas C., Nair, Asha A., Gonzalez, Michelle M., Sagstetter, Mary R., Baheti, Saurabh, McGovern, Dermot P. B., Friton, Jessica J., Papadakis, Konstantinos A., Gautam, Goel, Xavier, Ramnik J., Urrutia, Raul A., Faubion, William A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2017
Konular:
Molecular Bases of Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241744/
https://ncbi.nlm.nih.gov/pubmed/27909059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.749663
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