The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD)

Regulatory T (Treg) cells expressing the transcription factor FOXP3 play a pivotal role in maintaining immunologic self-tolerance. We and others have shown previously that EZH2 is recruited to the FOXP3 promoter and its targets in Treg cells. To further address the role for EZH2 in Treg cellular fun...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Sarmento, Olga F., Svingen, Phyllis A., Xiong, Yuning, Sun, Zhifu, Bamidele, Adebowale O., Mathison, Angela J., Smyrk, Thomas C., Nair, Asha A., Gonzalez, Michelle M., Sagstetter, Mary R., Baheti, Saurabh, McGovern, Dermot P. B., Friton, Jessica J., Papadakis, Konstantinos A., Gautam, Goel, Xavier, Ramnik J., Urrutia, Raul A., Faubion, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241744/
https://ncbi.nlm.nih.gov/pubmed/27909059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.749663
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