Disruption of FOXP3–EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation

BACKGROUND & AIMS: Forkhead box protein 3 (FOXP3)(+) regulatory T cell (Treg) dysfunction is associated with autoimmune diseases; however, the mechanisms responsible for inflammatory bowel disease pathophysiology are poorly understood. Here, we tested the hypothesis that a physical interaction b...

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Dettagli Bibliografici
Pubblicato in:Cell Mol Gastroenterol Hepatol
Autori principali: Bamidele, Adebowale O., Svingen, Phyllis A., Sagstetter, Mary R., Sarmento, Olga F., Gonzalez, Michelle, Braga Neto, Manuel B., Kugathasan, Subra, Lomberk, Gwen, Urrutia, Raul A., Faubion, William A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2018
Soggetti:
Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6260395/
https://ncbi.nlm.nih.gov/pubmed/30510991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.08.009
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