Polycomb Antagonizes p300/CREB-binding Protein-associated Factor to Silence FOXP3 in a Kruppel-like Factor-dependent Manner

Inducible gene expression underlies the epigenetically inherited differentiation program of most immune cells. We report that the promoter of the FOXP3 gene possesses two distinct functional states: an “off state” mediated by the polycomb histone methyltransferase complex and a histone acetyltransfe...

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Detalhes bibliográficos
Main Authors: Xiong, Yuning, Khanna, Sahil, Grzenda, Adrienne L., Sarmento, Olga F., Svingen, Phyllis A., Lomberk, Gwen A., Urrutia, Raul A., Faubion, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
DNA and Chromosomes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3464543/
https://ncbi.nlm.nih.gov/pubmed/22896699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.325332
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