Krüppel-like factor KLF10 deficiency predisposes to colitis through colonic macrophage dysregulation

Krüppel-like factor (KLF)-10 is an important transcriptional regulator of TGF-β(1) signaling in both CD8(+) and CD4(+) T lymphocytes. In the present study, we demonstrate a novel role for KLF10 in the regulation of TGFβRII expression with functional relevance in macrophage differentiation and activa...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Papadakis, Konstantinos A., Krempski, James, Svingen, Phyllis, Xiong, Yuning, Sarmento, Olga F., Lomberk, Gwen A., Urrutia, Raul A., Faubion, William A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Inflammation, Immunity, and Infection
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4669350/
https://ncbi.nlm.nih.gov/pubmed/26472224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00309.2015
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