Structure of the Toll/Interleukin-1 Receptor (TIR) Domain of the B-cell Adaptor That Links Phosphoinositide Metabolism with the Negative Regulation of the Toll-like Receptor (TLR) Signalosome

Ligand binding to Toll-like receptors (TLRs) results in dimerization of their cytosolic Toll/interleukin-1 receptor (TIR) domains and recruitment of post-receptor signal transducers into a complex signalosome. TLR activation leads to the production of transcription factors and pro-inflammatory molec...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Halabi, Samer, Sekine, Eiki, Verstak, Brett, Gay, Nicholas J., Moncrieffe, Martin C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241739/
https://ncbi.nlm.nih.gov/pubmed/27909057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.761528
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