Crystal Structures of the Toll/Interleukin-1 Receptor (TIR) Domains from the Brucella Protein TcpB and Host Adaptor TIRAP Reveal Mechanisms of Molecular Mimicry

The Toll/IL-1 receptor (TIR) domains are crucial innate immune signaling modules. Microbial TIR domain-containing proteins inhibit Toll-like receptor (TLR) signaling through molecular mimicry. The TIR domain-containing protein TcpB from Brucella inhibits TLR signaling through interaction with host a...

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Detalhes bibliográficos
Main Authors: Snyder, Greg A., Deredge, Daniel, Waldhuber, Anna, Fresquez, Theresa, Wilkins, David Z., Smith, Patrick T., Durr, Susi, Cirl, Christine, Jiang, Jiansheng, Jennings, William, Luchetti, Timothy, Snyder, Nathaniel, Sundberg, Eric J., Wintrode, Patrick, Miethke, Thomas, Xiao, T. Sam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3887195/
https://ncbi.nlm.nih.gov/pubmed/24275656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.523407
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