Brucella TIR Domain-containing Protein Mimics Properties of the Toll-like Receptor Adaptor Protein TIRAP

Toll-like receptors (TLRs) play essential roles in the activation of innate immune responses against microbial infections. TLRs and downstream adaptor molecules contain a conserved cytoplasmic TIR domain. TIRAP is a TIR domain-containing adaptor protein that recruits the signaling adaptor MyD88 to a...

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Hlavní autoři: Radhakrishnan, Girish K., Yu, Qiqi, Harms, Jerome S., Splitter, Gary A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Mechanisms of Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2665112/
https://ncbi.nlm.nih.gov/pubmed/19196716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805458200
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