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An alanine to proline mutation in the BB-loop of Toll-like receptor 3 TIR domain switches signalling adaptor specificity from TRIF to MyD88
A functionally important proline residue is highly conserved in the cytosolic TIR signalling domains of human Toll-like receptors (TLRs). The anti-viral Toll, TLR3, is unusual as it has alanine instead of proline at this position and is the only human TLR that associates directly with the adaptor mo...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3858240/ https://ncbi.nlm.nih.gov/pubmed/24198284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300849 |
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