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Identification of Interaction Sites for Dimerization and Adapter Recruitment in Toll/Interleukin-1 Receptor (TIR) Domain of Toll-like Receptor 4

Toll-like receptor signaling requires interactions of the Toll/IL-1 receptor (TIR) domains of the receptor and adapter proteins. Using the mammalian protein-protein interaction trap strategy, homology modeling, and site-directed mutagenesis, we identify the interaction surfaces in the TLR4 TIR domai...

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Detalhes bibliográficos
Main Authors: Bovijn, Celia, Ulrichts, Peter, De Smet, Anne-Sophie, Catteeuw, Dominiek, Beyaert, Rudi, Tavernier, Jan, Peelman, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281722/
https://ncbi.nlm.nih.gov/pubmed/22139835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.282350
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