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Toll/Interleukin-1 Receptor Domain Dimers as the Platform for Activation and Enhanced Inhibition of Toll-like Receptor Signaling

TIR (Toll/IL-1 receptor) domains mediate interactions between TLR (Toll-like) or IL-1 family receptors and signaling adapters. While homotypic TIR domain interactions mediate receptor activation they are also usurped by microbial TIR domain containing proteins for immunosuppression. Here we show the...

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Autors principals: Fekonja, Ota, Benčina, Mojca, Jerala, Roman
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3438932/
https://ncbi.nlm.nih.gov/pubmed/22829600
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.376186
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