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MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2
Injury-induced (Wallerian) axonal degeneration is regulated via the opposing actions of pro-degenerative factors such as SARM1 and a MAPK signal and pro-survival factors, the most important of which is the NAD(+) biosynthetic enzyme NMNAT2 that inhibits activation of the SARM1 pathway. Here we inves...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5241118/ https://ncbi.nlm.nih.gov/pubmed/28095293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.22540 |
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