Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease

The aggregation of the 42-residue form of the amyloid-β peptide (Aβ42) is a pivotal event in Alzheimer’s disease (AD). The use of chemical kinetics has recently enabled highly accurate quantifications of the effects of small molecules on specific microscopic steps in Aβ42 aggregation. Here, we explo...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Habchi, Johnny, Chia, Sean, Limbocker, Ryan, Mannini, Benedetta, Ahn, Minkoo, Perni, Michele, Hansson, Oskar, Arosio, Paolo, Kumita, Janet R., Challa, Pavan Kumar, Cohen, Samuel I. A., Linse, Sara, Dobson, Christopher M., Knowles, Tuomas P. J., Vendruscolo, Michele
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
PNAS Plus
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240708/
https://ncbi.nlm.nih.gov/pubmed/28011763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615613114
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