Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease

The aggregation of the 42-residue form of the amyloid-β peptide (Aβ42) is a pivotal event in Alzheimer’s disease (AD). The use of chemical kinetics has recently enabled highly accurate quantifications of the effects of small molecules on specific microscopic steps in Aβ42 aggregation. Here, we explo...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Habchi, Johnny, Chia, Sean, Limbocker, Ryan, Mannini, Benedetta, Ahn, Minkoo, Perni, Michele, Hansson, Oskar, Arosio, Paolo, Kumita, Janet R., Challa, Pavan Kumar, Cohen, Samuel I. A., Linse, Sara, Dobson, Christopher M., Knowles, Tuomas P. J., Vendruscolo, Michele
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2017
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240708/
https://ncbi.nlm.nih.gov/pubmed/28011763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615613114
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