Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease

The aggregation of the 42-residue form of the amyloid-β peptide (Aβ42) is a pivotal event in Alzheimer’s disease (AD). The use of chemical kinetics has recently enabled highly accurate quantifications of the effects of small molecules on specific microscopic steps in Aβ42 aggregation. Here, we explo...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Habchi, Johnny, Chia, Sean, Limbocker, Ryan, Mannini, Benedetta, Ahn, Minkoo, Perni, Michele, Hansson, Oskar, Arosio, Paolo, Kumita, Janet R., Challa, Pavan Kumar, Cohen, Samuel I. A., Linse, Sara, Dobson, Christopher M., Knowles, Tuomas P. J., Vendruscolo, Michele
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2017
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5240708/
https://ncbi.nlm.nih.gov/pubmed/28011763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615613114
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