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IL-15/IL-15Rα-mediated avidity maturation of memory CD8(+) T cells
T cell avidity is critical to viral clearance, but mechanisms of CD8(+) T cell avidity maturation are poorly understood. Here, we find that IL-15 mediates two mechanisms of avidity maturation. (i) By selection at the population level, IL-15 promotes greater survival of high- compared with low-avidit...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC524066/ https://ncbi.nlm.nih.gov/pubmed/15477598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406649101 |
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