Synergy of IL-21 and IL-15 in regulating CD8(+) T cell expansion and function

Interleukin (IL)-21 is the most recently recognized of the cytokines that share the common cytokine receptor γ chain (γ(c)), which is mutated in humans with X-linked severe combined immunodeficiency. We now report that IL-21 synergistically acts with IL-15 to potently promote the proliferation of bo...

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Main Authors: Zeng, Rong, Spolski, Rosanne, Finkelstein, Steven E., Oh, SangKon, Kovanen, Panu E., Hinrichs, Christian S., Pise-Masison, Cynthia A., Radonovich, Michael F., Brady, John N., Restifo, Nicholas P., Berzofsky, Jay A., Leonard, Warren J.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2005
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212766/
https://ncbi.nlm.nih.gov/pubmed/15630141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041057
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