IL-2 negatively regulates IL-7 receptor α chain expression in activated T lymphocytes

Interleukin (IL)-2 is a type I four-α-helical bundle cytokine that plays vital roles in antigen-mediated proliferation of peripheral blood T cells and also is critical for activation-induced cell death. We now demonstrate that IL-2 potently decreases expression of IL-7 receptor α chain (IL-7Rα) mRNA...

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Bibliographische Detailangaben
Hauptverfasser: Xue, Hai-Hui, Kovanen, Panu E., Pise-Masison, Cynthia A., Berg, Maria, Radovich, Michael F., Brady, John N., Leonard, Warren J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC129770/
https://ncbi.nlm.nih.gov/pubmed/12354940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.212214999
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