Different metabolic responses to PI3K inhibition in NSCLC cells harboring wild-type and G12C mutant KRAS

KRAS mutations in non-small-cell lung cancer (NSCLC) patients are considered a negative predictive factor and indicate poor response to anticancer treatments. KRAS mutations lead to activation of the PI3K/akt/mTOR pathway, whose inhibition remains a challenging clinical target. Since the PI3K/akt/mT...

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Bibliografiske detaljer
Udgivet i:Oncotarget
Main Authors: Caiola, Elisa, Brunelli, Laura, Marabese, Mirko, Broggini, Massimo, Lupi, Monica, Pastorelli, Roberta
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5239488/
https://ncbi.nlm.nih.gov/pubmed/27283493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9849
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