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Different metabolic responses to PI3K inhibition in NSCLC cells harboring wild-type and G12C mutant KRAS
KRAS mutations in non-small-cell lung cancer (NSCLC) patients are considered a negative predictive factor and indicate poor response to anticancer treatments. KRAS mutations lead to activation of the PI3K/akt/mTOR pathway, whose inhibition remains a challenging clinical target. Since the PI3K/akt/mT...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5239488/ https://ncbi.nlm.nih.gov/pubmed/27283493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9849 |
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