Base excision repair-mediated resistance to cisplatin in KRAS(G12C) mutant NSCLC cells

KRAS mutations in NSCLC are supposed to indicate a poor prognosis and poor response to anticancer treatments but this feature lacks a mechanistic basis so far. In tumors, KRAS was found to be mutated mostly at codons 12 and 13 and a pool of mutations differing in the base alteration and the amino ac...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Caiola, Elisa, Salles, Daniela, Frapolli, Roberta, Lupi, Monica, Rotella, Giuseppe, Ronchi, Anna, Garassino, Marina Chiara, Mattschas, Nikola, Colavecchio, Stefano, Broggini, Massimo, Wiesmüller, Lisa, Marabese, Mirko
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4745782/
https://ncbi.nlm.nih.gov/pubmed/26353932
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