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Molecular determinants of response to PI3K/akt/mTOR and KRAS pathways inhibitors in NSCLC cell lines

Despite the impressive results obtained in the preclinical setting, all the inhibitors targeting two central cascades in cancer, the PI3K/akt/mTOR and the KRAS/MEK/ERK pathways, have shown, apart from very few exceptions, disappointing efficacy when translated to the clinic. One of the main reasons...

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Bibliographische Detailangaben
Veröffentlicht in:Am J Cancer Res
Hauptverfasser: Iezzi, Alice, Caiola, Elisa, Colombo, Marika, Marabese, Mirko, Broggini, Massimo
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7783749/
https://ncbi.nlm.nih.gov/pubmed/33415013
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