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Glutaminase Inhibition on NSCLC Depends on Extracellular Alanine Exploitation

Non-small-cell lung cancer (NSCLC) cell lines vary in their sensitivity to glutaminase inhibitors, so it is important to identify the metabolic assets underling their efficacy in cancer cells. Even though specific genetic lesions such as in KRAS and LKB1 have been associated with reliance on glutami...

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Detalhes bibliográficos
Publicado no:Cells
Main Authors: Caiola, Elisa, Colombo, Marika, Sestito, Giovanna, Lupi, Monica, Marabese, Mirko, Pastorelli, Roberta, Broggini, Massimo, Brunelli, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7465377/
https://ncbi.nlm.nih.gov/pubmed/32718002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9081766
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