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Induced fit of the peptidyl-transferase center of the ribosome and conformational freedom of the esterified amino acids

The catalytic site of most enzymes can efficiently handle only one substrate. In contrast, the ribosome is capable of polymerizing at a similar rate at least 20 different kinds of amino acids from aminoacyl-tRNA carriers while using just one catalytic site, the peptidyl-transferase center (PTC). An...

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Bibliografiske detaljer
Udgivet i:RNA
Hovedforfatter: Lehmann, Jean
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5238797/
https://ncbi.nlm.nih.gov/pubmed/27879432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.057273.116
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