The ribosome can discriminate the chirality of amino acids within its peptidyl-transferase center

The cellular translational machinery (TM) synthesizes proteins using exclusively L- or achiral aminoacyl-tRNAs (aa-tRNAs), despite the presence of D-amino acids in nature and their ability to be aminoacylated onto tRNAs by aa-tRNA synthetases. The ubiquity of L-amino acids in proteins has led to the...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Englander, Michael T., Avins, Joshua L., Fleisher, Rachel C., Liu, Bo, Effraim, Philip R., Wang, Jiangning, Schulten, Klaus, Leyh, Thomas S., Gonzalez, Ruben L., Cornish, Virginia W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434717/
https://ncbi.nlm.nih.gov/pubmed/25918365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424712112
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