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Transition state chirality and role of the vicinal hydroxyl in the ribosomal peptidyl transferase reaction

The ribosomal peptidyl transferase is a biologically essential catalyst responsible for protein synthesis. The reaction is expected to proceed through a transition state approaching tetrahedral geometry with a specific chirality. To establish that stereospecificity, we synthesized two diastereomers...

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Bibliografische gegevens
Hoofdauteurs: Huang, Kevin S., Carrasco, Nicolas, Pfund, Emmanuel, Strobel, Scott A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854833/
https://ncbi.nlm.nih.gov/pubmed/18672893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800299u
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