The Nox1/4 dual inhibitor GKT137831 or Nox4 knockdown inhibits Angiotensin-II-induced adult mouse cardiac fibroblast proliferation and migration. AT1 physically associates with Nox4

Both oxidative stress and inflammation contribute to chronic hypertension-induced myocardial fibrosis and adverse cardiac remodeling. Here we investigated whether angiotensin (Ang)-II-induced fibroblast proliferation and migration are NADPH oxidase (Nox) 4/ROS and IL-18 dependent. Our results show t...

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Vydáno v:J Cell Physiol
Hlavní autoři: Somanna, Naveen K., Valente, Anthony J., Krenz, Maike, Fay, William P., Delafontaine, Patrice, Chandrasekar, Bysani
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5237386/
https://ncbi.nlm.nih.gov/pubmed/26445208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.25210
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