Inhibition of NOX1/4 with GKT137831: a potential novel treatment to attenuate neuroglial cell inflammation in the retina

BACKGROUND: Inflammation and the excess production of reactive oxygen species (ROS) contribute significantly to the pathogenesis of ischemic retinopathies such as diabetic retinopathy and retinopathy of prematurity. We hypothesized that GKT137831, a dual inhibitor of NADPH oxidases (NOX) 1 and NOX4,...

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Udgivet i:J Neuroinflammation
Main Authors: Deliyanti, Devy, Wilkinson-Berka, Jennifer L.
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2015
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Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4518508/
https://ncbi.nlm.nih.gov/pubmed/26219952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-015-0363-z
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