The Nox4 Inhibitor GKT137831 Attenuates Hypoxia-Induced Pulmonary Vascular Cell Proliferation

Increased NADP reduced (NADPH) oxidase 4 (Nox4) and reduced expression of the nuclear hormone receptor peroxisome proliferator-activated receptor γ (PPARγ) contribute to hypoxia-induced pulmonary hypertension (PH). To examine the role of Nox4 activity in pulmonary vascular cell proliferation and PH,...

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Autori principali: Green, David E., Murphy, Tamara C., Kang, Bum-Yong, Kleinhenz, Jennifer M., Szyndralewiez, Cédric, Page, Patrick, Sutliff, Roy L., Hart, C. Michael
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Thoracic Society 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3547100/
https://ncbi.nlm.nih.gov/pubmed/22904198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2011-0418OC
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