Interleukin-17A stimulates cardiac fibroblast proliferation and migration via negative regulation of the dual-specificity phosphatase MKP-1/DUSP-1

The dual-specificity mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) inactivates MAP kinases by dephosphorylation. Here we show that the proinflammatory cytokine interleukin (IL)-17A induces adult mouse primary cardiac fibroblast (CF) proliferation and migration via IL-17 receptor A//I...

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Detalhes bibliográficos
Main Authors: Valente, Anthony J., Yoshida, Tadashi, Gardner, Jason D., Somanna, Naveen, Delafontaine, Patrice, Chandrasekar, Bysani
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339406/
https://ncbi.nlm.nih.gov/pubmed/22037550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2011.10.010
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