β2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo

Both the sympathetic nervous system and the proinflammatory cytokine interleukin-18 (IL-18) play key roles in the pathophysiology of the hypertrophied failing heart. IL-18 binding protein (IL-18BP), a natural inhibitor of IL-18, counters its biological effects. β-AR stimulation induces IL-18 express...

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Bibliographische Detailangaben
Hauptverfasser: Murray, David R., Mummidi, Srinivas, Valente, Anthony J., Yoshida, Tadashi, Somanna, Naveen K., Delafontaine, Patrice, Dinarello, Charles A., Chandrasekar, Bysani
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3246026/
https://ncbi.nlm.nih.gov/pubmed/22004899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2011.09.022
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