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Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy

Angiotensin-II (Ang-II) plays a key role in myocardial hypertrophy, remodeling and failure. We investigated whether Ang-II-induced cardiomyocyte hypertrophy is dependent on WNT1 inducible signaling pathway protein 1 (WISP1), a pro growth factor. Ang-II induced hypertrophy and WISP1 expression in neo...

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Detalhes bibliográficos
Main Authors: Shanmugam, Prakashsrinivasan, Valente, Anthony J., Prabhu, Sumanth D., Venkatesan, Balachandar, Yoshida, Tadashi, Delafontaine, Patrice, Chandrasekar, Bysani
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3192329/
https://ncbi.nlm.nih.gov/pubmed/21376054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2011.02.012
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