Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-κB activation

IL-18 and the extracellular matrix metalloproteinase (MMP) inducer (EMMPRIN) stimulate the expression of proinflammatory cytokines and MMPs and are elevated in myocardial hypertrophy, remodeling, and failure. Here, we report several novel findings in primary cardiomyocytes treated with IL-18. First,...

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Main Authors: Reddy, Venkatapuram Seenu, Prabhu, Sumanth D., Mummidi, Srinivas, Valente, Anthony J., Venkatesan, Balachandar, Shanmugam, Prakashsrinivasan, Delafontaine, Patrice, Chandrasekar, Bysani
Format: Artigo
Language:Inglês
Published: American Physiological Society 2010
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2957343/
https://ncbi.nlm.nih.gov/pubmed/20693392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00451.2010
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