WNT1-Inducible Signaling Pathway Protein-1 Activates Diverse Cell Survival Pathways and Blocks Doxorubicin-induced Cardiomyocyte Death

The anthracycline antibiotic doxorubicin (DOX) is a potent cancer chemotherapeutic agent that exerts both acute and chronic cardiotoxicity. Here we show that in adult mouse cardiomyocytes, DOX activates (i) the pro-apoptotic p53, (ii) p38MAPK and JNK, (iii) Bax translocation, (iv) cytochrome c relea...

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Detalhes bibliográficos
Main Authors: Venkatesan, Balachandar, Prabhu, Sumanth D., Venkatachalam, Kaliyamurthi, Mummidi, Srinivas, Valente, Anthony J., Clark, Robert A., Delafontaine, Patrice, Chandrasekar, Bysani
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2885703/
https://ncbi.nlm.nih.gov/pubmed/20074638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2010.01.005
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