EMMPRIN activates multiple transcription factor pathways in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-κ B and MKK7/JNK/AP-1 signaling

The transmembrane glycoprotein extracellular matrix metalloproteinase inducer (EMMPRIN), and the pleiotropic proinflammatory cytokine interleukin (IL)-18, play critical roles in myocardial remodeling, by inducing matrix degrading metalloproteinases (MMPs). Previously we showed that IL-18 induces EMM...

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Bibliographic Details
Main Authors: Venkatesan, Balachandar, Valente, Anthony J., Prabhu, Sumanth D., Shanmugam, Prakashsrinivasan, Delafontaine, Patrice, Chandrasekar, Bysani
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042694/
https://ncbi.nlm.nih.gov/pubmed/20538003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.05.007
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