Creating new DNA binding specificities in the yeast transcriptional activator GCN4 by combining selected amino acid substitutions.

The specificity of the GCN4/DNA complex is mediated by a complicated network of interactions between the basic regions of both GCN4 monomers and their target halfsites. According to X-ray analyses (1, 2) one particular thymine of the target sequence is recognized by serine -11 and alanine -15 (we de...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Suckow, M, Madan, A, Kisters-Woike, B, von Wilcken-Bergmann, B, Müller-Hill, B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1994
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC523674/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8036145/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.12.2198
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