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Creating new DNA binding specificities in the yeast transcriptional activator GCN4 by combining selected amino acid substitutions.
The specificity of the GCN4/DNA complex is mediated by a complicated network of interactions between the basic regions of both GCN4 monomers and their target halfsites. According to X-ray analyses (1, 2) one particular thymine of the target sequence is recognized by serine -11 and alanine -15 (we de...
Gorde:
| Egile Nagusiak: | , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
1994
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| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC523674/ https://ncbi.nlm.nih.gov/pubmed/8036145 |
| Etiketak: |
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