Creating new DNA binding specificities in the yeast transcriptional activator GCN4 by combining selected amino acid substitutions.
The specificity of the GCN4/DNA complex is mediated by a complicated network of interactions between the basic regions of both GCN4 monomers and their target halfsites. According to X-ray analyses (1, 2) one particular thymine of the target sequence is recognized by serine -11 and alanine -15 (we de...
Guardat en:
| Publicat a: | Nucleic Acids Res |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
1994
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| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC523674/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8036145/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/22.12.2198 |
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