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Determination of the Kinetics and Thermodynamics of Ligand Binding to a Specific Inactive Conformation in Protein Kinases
Recent interest in inactive kinase conformations has generated the need to develop new biophysical tools to study them. Here, we describe the use of a fluorescent probe that selectively and potently binds to kinases in inactive, “DFG-out” conformations to obtain valuable thermodynamic and kinetic in...
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| Pubblicato in: | Methods Mol Biol |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5228460/ https://ncbi.nlm.nih.gov/pubmed/22956140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-62703-008-3_12 |
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